Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | IL5 | P05113 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rofleponide SCHEMBL7196822 | 1.00 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL74762 | 1.00 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL23803954 | 1.00 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL8505525 | 1.00 | NR3C1 (0.68) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| Rofleponide SCHEMBL6449744 | 0.97 | NR3C1 (0.64) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8204804 | 0.93 | NR3C1 (0.67) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL7081817 | 0.93 | NR3C1 (0.70) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8674574 | 0.93 | NR3C1 (0.70) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL6323559 | 0.92 | NR3C1 (0.57) | NR3C1CYP3A4LMNAHIF1AHSD17B10 | |
| SCHEMBL8138913 | 0.92 | NR3C1 (0.66) | NR3C1CYP3A4LMNAHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002088169-A2 | PREPARATION OF GLUCOCORTICOSTEROIDS, 16, 17 ACETALS OR KETALS OF PREGNANE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-07 | — | — | WO | claimed |
| US-5888995-A | ANTIINFLAMMATORY AND ANTIALLERGENIC AGENTS; A NOVEL GLUCOCORTICOSTEROID | ASTRA AKTIEBOLAG (SE) | 1999-03-30 | — | — | US | claimed |
| EP-1848444-A1 | PROCESSES FOR MAKING LACTOSE UTILIZING PRE-CLASSIFICATION TECHNIQUES AND PHARMACEUTICAL FORMULATIONS FORMED THEREFROM | GLAXO GROUP LIMITED (GB) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006086270-A1 | PROCESSES FOR MAKING LACTOSE UTILIZING PRE-CLASSIFICATION TECHNIQUES AND PHARMACEUTICAL FORMULATIONS FORMED THEREFROM | GLAXO GROUP LIMITED (GB) | 2006-08-17 | — | — | WO | disclosed |
| US-20040019025-A1 | Medical compositions comprising (r,r)-formoterol and rofleponide | SMITHKLINE BEECHAM CORPORATION | 2004-01-29 | — | — | US | disclosed |
| US-20030096874-A1 | Respiratory compositions | SMITHKLINE BEECHAM CORPORATION | 2003-05-22 | — | — | US | disclosed |
| EP-1274434-A1 | MEDICAL COMBINATIONS COMPRISING TIOTROPIUM AND ROFLEPONIDE | GLAXO GROUP LIMITED (GB) | 2003-01-15 | — | — | EP | disclosed |
| EP-1274441-A1 | RESPIRATORY COMPOSITIONS | GLAXO GROUP LIMITED (GB) | 2003-01-15 | — | — | EP | disclosed |
| WO-2002088169-A2 | PREPARATION OF GLUCOCORTICOSTEROIDS, 16, 17 ACETALS OR KETALS OF PREGNANE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-07 | — | — | WO | disclosed |
| WO-2001078736-A1 | MEDICAL COMBINATIONS COMPRISING TIOTROPIUM AND ROFLEPONIDE | GLAXO GROUP LIMITED (GB) | 2001-10-25 | — | — | WO | disclosed |
| WO-2001078746-A1 | RESPIRATORY COMPOSITIONS | GLAXO GROUP LIMITED (GB) | 2001-10-25 | — | — | WO | disclosed |
| US-5939409-A | CONDENSATION OF ALDEHYDE WITH STEROIDIOL TO FORM AN ACETAL GROUPS | ASTRA AKTIEBOLAG (SE) | 1999-08-17 | — | — | US | disclosed |
| EP-0678097-B1 | NOVEL COLON- OR ILEUM-SPECIFIC STEROID DERIVATIVES | ASTRA AB (SE) | 1999-08-11 | — | — | EP | disclosed |
| US-5908833-A | GLUCOCORTICOSTEROID CHEMICALLY BOUND TO A SUGAR | AKTIEBOLAGET ASTRA (SE) | 1999-06-01 | — | — | US | disclosed |
| EP-0570454-B1 | NOVEL STEROIDS | ASTRA AB (SE) | 1999-04-07 | — | — | EP | disclosed |
| US-5888995-A | ANTIINFLAMMATORY AND ANTIALLERGENIC AGENTS; A NOVEL GLUCOCORTICOSTEROID | ASTRA AKTIEBOLAG (SE) | 1999-03-30 | — | — | US | disclosed |
| EP-0572451-B1 | NOVEL STEROID ESTERS | ASTRA AB (SE) | 1998-04-01 | — | — | EP | disclosed |
| US-5674861-A | GLUCOCORTICOSTEROIDS FOR LOCAL TREATMENT OF INFLAMMATORY DISORDERS | ASTRA AKTIEBOLAG (SE) | 1997-10-07 | — | — | US | disclosed |
| US-5614514-A | Steroid esters | AKTIEBOLAGET ASTRA (SE) | 1997-03-25 | — | — | US | disclosed |