Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.55 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11901256 | 0.86 | NOD2 (0.56) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL8188816 | 0.85 | AGTR1 (0.66) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL28408418 | 0.76 | AGTR1 (0.70) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL11900992 | 0.75 | PCSK9 (0.67) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL11900468 | 0.75 | AGTR1 (0.70) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL6858321 | 0.74 | PPARG (0.57) | HTR6 | |
| SCHEMBL17297375 | 0.74 | HTR6 (0.67) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL29357508 | 0.74 | HTR6 (0.67) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL11900581 | 0.74 | AGTR1 (0.57) | AGTR1PCSK9PSEN1PSEN2APH1B | |
| SCHEMBL11900678 | 0.73 | PCSK9 (0.56) | AGTR1PCSK9PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36832-E | AN ANTICHOLESTEROL AGENT TREATING HYPERCHOLESTEROLEMIA | NIHON NOHYAKU CO., LTD (JP) | 2000-08-22 | — | — | US | disclosed |
| EP-0613894-B1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO LTD (JP) | 1999-05-06 | — | — | EP | disclosed |
| US-5464863-A | Anticholesterol agents | NIHON NOHYAKU CO., LTD. (JP) | 1995-11-07 | — | — | US | disclosed |
| EP-0613894-A1 | N-Heteroaryl-N'-phenylurea derivatives, their production and use | NIHON NOHYAKU CO., LTD. (JP) | 1994-09-07 | — | — | EP | disclosed |