Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 19/20 | 0.54 |
| ▸ | NOS1 | P29475 | 11/20 | 0.54 |
| ▸ | NOS3 | P29474 | 14/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8193125 | 0.92 | NOS2 (0.58) | NOS2NOS1NOS3 | |
| SCHEMBL8194863 | 0.86 | NOS2 (0.47) | NOS2NOS1NOS3 | |
| SCHEMBL8193587 | 0.86 | NOS2 (0.47) | NOS2NOS1NOS3 | |
| SCHEMBL8218288 | 0.86 | NOS2 (0.47) | NOS2NOS1NOS3 | |
| SCHEMBL8186402 | 0.76 | TAAR1 (0.44) | NOS2NOS1NOS3 | |
| SCHEMBL8186392 | 0.75 | NOS2 (0.85) | NOS2NOS1NOS3 | |
| SCHEMBL8193120 | 0.71 | NOS2 (0.38) | NOS2NOS1NOS3 | |
| SCHEMBL6191141 | 0.71 | NOS1 (1.00) | NOS2NOS1NOS3NPY1R | |
| SCHEMBL7090223 | 0.71 | NOS1 (1.00) | NOS2NOS1NOS3NPY1R | |
| SCHEMBL8063238 | 0.69 | NOS2 (0.60) | NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | claimed |
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |