Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 4/20 | 0.32 |
| ▸ | NOS2 | P35228 | 4/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14081363 | 1.00 | KDM4E (0.38) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL18757668 | 0.92 | — | — | |
| SCHEMBL10123519 | 0.82 | TSHR (0.32) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4023693 | 0.82 | TSHR (0.32) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4447758 | 0.81 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4334172 | 0.77 | PARP1 (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL2209103 | 0.77 | — | — | |
| SCHEMBL4447755 | 0.77 | PARP1 (0.42) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL12475847 | 0.75 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4548364 | 0.75 | MAPK1 (0.32) | KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |