Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205692 | 0.90 | MAPK8 (0.47) | MAPK8MAPK9MAPK10HPGDSCA1 | |
| SCHEMBL8206930 | 0.89 | MMP13 (0.46) | MAPK8MAPK9HPGDSROCK2ROCK1 | |
| SCHEMBL8199927 | 0.88 | CNR2 (0.50) | CYP11B1HPGDSKLKB1KLK1ADORA2A | |
| SCHEMBL8209069 | 0.88 | CNR2 (0.47) | ADORA2AADORA1 | |
| SCHEMBL8207800 | 0.86 | ROCK2 (0.47) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL12853352 | 0.85 | CNR2 (0.52) | — | |
| SCHEMBL12853345 | 0.85 | CTSA (0.47) | MAPK8MAPK9MAPK10CYP11B1ADORA2A | |
| SCHEMBL8205721 | 0.85 | MAPK8 (0.47) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8211821 | 0.85 | ROCK2 (0.47) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8212427 | 0.85 | SMN1; SMN2 (0.41) | MAPK8MAPK9HPGDSROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |