Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28802106 | 0.88 | ALOX12 (0.64) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL4703988 | 0.86 | KDM4E (1.00) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL4496604 | 0.80 | L3MBTL1 (0.76) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL24970013 | 0.74 | KDM4E (0.68) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL31398632 | 0.74 | ALDH1A1 (0.77) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL7494798 | 0.74 | KMT2A (0.55) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL16674539 | 0.73 | KDM4E (0.70) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL23413572 | 0.73 | NPC1 (0.76) | KDM4EKMT2AMAPTMEN1MAPK10 | |
| SCHEMBL11932743 | 0.73 | EPHX1 (0.65) | KDM4EKMT2AMAPTMEN1ALOX12 | |
| SCHEMBL14095084 | 0.73 | KDM4E (0.74) | KDM4EKMT2AMAPTMEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071524-A1 | 2-NH-PYRIDONES AND PYRIMIDONES AS MRS INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |