Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLR1A | O95602 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194184 | 1.00 | PTGER4 (0.37) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL13035249 | 0.93 | PTGER4 (0.38) | PTGER4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL13035288 | 0.92 | FOLH1 (0.36) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL13035132 | 0.92 | FOLH1 (0.36) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL13035264 | 0.91 | PTGER4 (0.36) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL13035109 | 0.91 | PTGER4 (0.36) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL8196660 | 0.90 | TACR3 (0.42) | CNR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL13035050 | 0.89 | MT-CO2 (0.35) | CNR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL8194380 | 0.87 | GUCY1B2 (0.38) | PTGER4CNR1GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL13035070 | 0.84 | PTGER4 (0.36) | PTGER4GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | PTGER4 2547/4885CNR1 1294/4885GUCY1B2 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.