Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199963 | 0.93 | HTR2C (0.46) | HTR2CDRD2MCHR1PRCPPRMT5 | |
| SCHEMBL8202304 | 0.93 | HTR2C (0.47) | HTR2CDRD2MCHR1PRCPSIGMAR1 | |
| SCHEMBL8200324 | 0.90 | HTR2C (0.45) | HTR2CDRD2MCHR1PRCPUSP5 | |
| SCHEMBL8201705 | 0.88 | HTR2C (0.46) | HTR2CDRD2MCHR1PRCPSIGMAR1 | |
| SCHEMBL8202809 | 0.87 | HTR2C (0.45) | HTR2CDRD2MCHR1PRCPPRMT5 | |
| SCHEMBL8202320 | 0.86 | USP5 (0.52) | HTR2CDRD2MCHR1SIGMAR1USP5 | |
| SCHEMBL8199804 | 0.85 | HTR2C (0.49) | HTR2CDRD2MCHR1SIGMAR1 | |
| SCHEMBL8588802 | 0.85 | HTR2C (0.48) | HTR2CDRD2MCHR1SIGMAR1USP5 | |
| SCHEMBL8200268 | 0.84 | HTR2C (0.46) | HTR2CDRD2MCHR1PRCPUSP5 | |
| SCHEMBL8198570 | 0.84 | HTR2C (0.47) | HTR2CDRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |