Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198570 | 0.91 | HTR2C (0.47) | HTR2CALDH1A1OPRM1OPRK1DRD2 | |
| SCHEMBL8202320 | 0.90 | USP5 (0.52) | HTR2CDRD2MCHR1SIGMAR1 | |
| SCHEMBL8198781 | 0.90 | HTR2C (0.46) | HTR2CALDH1A1DRD2MEN1KMT2A | |
| SCHEMBL8202767 | 0.89 | HTR2C (0.44) | HTR2COPRM1OPRK1DRD2MCHR1 | |
| SCHEMBL8203525 | 0.89 | SIGMAR1 (0.46) | HTR2CALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL8588802 | 0.89 | HTR2C (0.48) | HTR2COPRM1OPRK1DRD2MCHR1 | |
| SCHEMBL8202304 | 0.88 | HTR2C (0.47) | HTR2CDRD2MCHR1SIGMAR1 | |
| SCHEMBL8204772 | 0.87 | HTR2C (0.50) | HTR2CDRD2MCHR1SIGMAR1 | |
| SCHEMBL8198980 | 0.87 | HTR2C (0.55) | HTR2CDRD2MCHR1SIGMAR1 | |
| SCHEMBL8200250 | 0.87 | HTR2C (0.44) | HTR2CDRD2SIGMAR1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |