Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198781 | 0.95 | HTR2C (0.46) | HTR2CDRD2ALDH1A1GLACHRM4 | |
| SCHEMBL8191651 | 0.94 | MCHR1 (0.48) | HTR2CSMN1; SMN2SLC5A7OPRM1OPRK1 | |
| SCHEMBL8203525 | 0.94 | SIGMAR1 (0.46) | HTR2CALDH1A1GLACHRM4SIGMAR1 | |
| SCHEMBL8202264 | 0.93 | CHRM4 (0.50) | HTR2CSMN1; SMN2SLC5A7OPRM1OPRK1 | |
| SCHEMBL8200603 | 0.93 | HTR2C (0.49) | HTR2CSMN1; SMN2SLC5A7DRD2ALDH1A1 | |
| SCHEMBL8199695 | 0.92 | SLC6A2 (0.46) | HTR2COPRM1OPRK1DRD2DRD4 | |
| SCHEMBL8199804 | 0.91 | HTR2C (0.49) | HTR2COPRM1OPRK1DRD2ALDH1A1 | |
| SCHEMBL8588802 | 0.90 | HTR2C (0.48) | HTR2CSLC5A7OPRM1OPRK1MAPT | |
| SCHEMBL8199074 | 0.89 | HTR2C (0.48) | HTR2CSMN1; SMN2OPRM1OPRK1DRD2 | |
| SCHEMBL8200656 | 0.89 | SMN1; SMN2 (0.53) | HTR2CSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |