Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 2/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.50 |
| ▸ | GUSB | P08236 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31716664 | 1.00 | TNKS2 (0.53) | TNKS2PARP1BRD4TOP2ATOP2B | |
| SCHEMBL30782682 | 0.84 | BRD4 (0.55) | TNKS2PARP1BRD4GUSBKMT2A | |
| SCHEMBL689576 | 0.84 | BRD4 (0.55) | TNKS2PARP1BRD4GUSBKMT2A | |
| SCHEMBL8189588 | 0.84 | LMNA (0.43) | PARP1TOP2ATOP2BKMT2AMMP13 | |
| SCHEMBL8198084 | 0.84 | KDM4E (0.46) | PARP1KMT2ATP53ALDH1A1KDM4E | |
| SCHEMBL8199597 | 0.83 | KDM4C (0.59) | MAPT | |
| SCHEMBL8196890 | 0.82 | PARP14 (0.42) | TNKS2PARP1TOP2ATOP2BMMP13 | |
| SCHEMBL8189585 | 0.81 | PARP1 (0.55) | PARP1KMT2AMMP13ALDH1A1KDM4E | |
| SCHEMBL8198835 | 0.81 | PARP1 (0.55) | TNKS2PARP1TNKS | |
| SCHEMBL8188061 | 0.80 | ALDH1A1 (0.36) | BRD4TOP2ATOP2BKMT2AMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |