Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189588 | 0.87 | LMNA (0.43) | TSHRKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL13343558 | 0.86 | TSHR (0.51) | PARP14TSHRENPP1KDM4EHTT | |
| SCHEMBL8190554 | 0.85 | KDM4E (0.40) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL8200741 | 0.82 | TNKS2 (0.53) | KDM4EHPGDALDH1A1MMP13TOP2A | |
| SCHEMBL31716664 | 0.82 | TNKS2 (0.53) | KDM4EHPGDALDH1A1MMP13TOP2A | |
| SCHEMBL8196893 | 0.81 | MAPT (0.43) | KDM4EALDH1A1LMNASMN1; SMN2TNKS | |
| SCHEMBL8198084 | 0.80 | KDM4E (0.46) | PARP14TYMSKDM4EHPGDALDH1A1 | |
| SCHEMBL8199597 | 0.79 | KDM4C (0.59) | — | |
| SCHEMBL8195657 | 0.78 | PARP1 (0.46) | TYMSKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL161361 | 0.76 | ALDH1A1 (0.56) | TSHRTYMSKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |