Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 8/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167654 | 0.88 | HTR2A (0.59) | HTR2ARETHRH1ACP3HTR2C | |
| SCHEMBL8994177 | 0.83 | HTR2A (0.66) | HTR2ARETHRH1HTR2CMAPT | |
| SCHEMBL11877356 | 0.81 | HTR2A (0.79) | HTR2ARETHRH1HTR2CCHRM1 | |
| SCHEMBL11891459 | 0.81 | SIGMAR1 (0.50) | HTR2ARETHRH1OPRM1HTR2C | |
| SCHEMBL8993284 | 0.79 | HTR2A (0.52) | HTR2AHRH1OPRM1HTR2CCHRM1 | |
| SCHEMBL9875531 | 0.79 | HTR2A (0.63) | HTR2ARETHRH1ACP3HTR2C | |
| SCHEMBL8859025 | 0.79 | HTR2A (0.49) | HTR2ARETHRH1ACP3HTR2C | |
| SCHEMBL80413 | 0.77 | SIGMAR1 (0.56) | — | |
| SCHEMBL8271368 | 0.77 | HTR2A (0.81) | HTR2ARETHRH1OPRM1HTR2C | |
| SCHEMBL8271379 | 0.77 | HTR2A (0.81) | HTR2ARETHRH1HTR2CCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738262-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2000-04-19 | — | — | EP | disclosed |
| US-6043239-A | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF THE N-SUBSTITUENT; TREATMENT OF PAINFUL, HYPERALGESIC AND/OR INFLAMMATORY CONDITIONS | NOVO NORDISK A/S (DK) | 2000-03-28 | — | — | US | disclosed |
| EP-0869777-A1 | NOVEL METHOD | NOVO NORDISK A/S (DK) | 1998-10-14 | — | — | EP | disclosed |
| US-5668129-A | ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 1997-09-16 | — | — | US | disclosed |
| WO-1997022338-A1 | NOVEL METHOD | NOVO NORDISK A/S (DK) | 1997-06-26 | — | — | WO | disclosed |
| US-5595989-A | ANTIINFLAMMATORY AGENTS AND ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 1997-01-21 | — | — | US | disclosed |
| EP-0738262-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-23 | — | — | EP | disclosed |
| WO-1995018793-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1995-07-13 | — | — | WO | disclosed |