Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.53 |
| ▸ | CTSK | P43235 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142811 | 0.93 | CTSS (0.60) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL8201088 | 0.92 | CTSS (0.59) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL14142816 | 0.92 | CTSS (0.54) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL8200884 | 0.91 | RORC (0.47) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL3169210 | 0.91 | CTSS (0.63) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL8206724 | 0.91 | RORC (0.47) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL3179568 | 0.90 | CTSS (0.62) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL14142813 | 0.90 | CTSS (0.54) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL14142743 | 0.90 | CTSS (0.53) | CTSSCTSKCTSLCTSBPRKAA2 | |
| SCHEMBL8242962 | 0.89 | CTSS (0.55) | CTSSCTSKCTSLCTSBPRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052934-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | WO | disclosed |