Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961973 | 0.88 | HTR2A (0.68) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL14277003 | 0.87 | POLB (0.61) | CHRM2CHRM1DRD3DRD2CHRM3 | |
| SCHEMBL7168298 | 0.86 | HTR2A (0.66) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL13051501 | 0.83 | HTR2A (0.78) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL5711025 | 0.82 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL29833637 | 0.82 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL8201084 | 0.81 | HTR2A (0.59) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL8859019 | 0.79 | SLC6A4 (0.61) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL9404599 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 | |
| SCHEMBL22018905 | 0.79 | HTR2A (0.61) | HTR2ASLC6A4SLC6A2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414806-A1 | NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC | NOVO NORDISK A/S (DK) | 2004-05-06 | — | — | EP | disclosed |
| US-20030055076-A1 | Novel compounds, their preparation and use | NOVO NORDISK A/S (DK) | 2003-03-20 | — | — | US | disclosed |
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | disclosed |
| WO-2003011834-A1 | NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC | NOVO NORDISK A/S (DK) | 2003-02-13 | — | — | WO | disclosed |
| US-6468996-B1 | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ACTIVATORS; TREATMENT OF DIABETES AND OBESITY. | NOVO NORDISK A/S (DK) | 2002-10-22 | — | — | US | disclosed |
| US-20020115657-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma | JEPPESEN LONE (DK) | 2002-08-22 | — | — | US | disclosed |
| US-20020111344-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma activators | JEPPESEN LONE (DK) | 2002-08-15 | — | — | US | disclosed |
| US-20020103188-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma activators | JEPPESEN LONE (DK) | 2002-08-01 | — | — | US | disclosed |
| US-6133268-A | 1,4-disubstituted piperazines | NOVO NORDISK A/S (DK) | 2000-10-17 | — | — | US | disclosed |
| US-6040302-A | ANTIINFLAMMATORY AGENTS TREATING RHEUMATOID ARTHRITIS, MIGRAINE OR ITCHING, INSULIN RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS AND AGEING-ASSOCIATED OBESITY | NOVO NORDISK A/S (DK) | 2000-03-21 | — | — | US | disclosed |
| US-6004961-A | ANTIINFLAMMATORY AGENTS, ANALGESICS; NON-INSULIN-DEPENDENT DIABETES; AGE-RELATED OBESITY; DIBENZO(D,G)(1,3,6)DIOXAZOCINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1999-12-21 | — | — | US | disclosed |
| EP-0585314-A1 | NOVEL HETEROCYCLIC CARBOXYLIC ACIDS. | NOVO NORDISK AS (DK) | 1994-03-09 | — | — | EP | disclosed |
| WO-1992020658-A1 | NOVEL HETEROCYCLIC CARBOXYLIC ACIDS | NOVO NORDISK A/S (DK) | 1992-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103188-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma activators | PPARG, PPARA, PPARD | HTR2A 1523/4885SLC6A4 4440/4885SLC6A2 4676/4885 |
| US-20020115657-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma | PPARG, PPARA, PPARD | HTR2A 1457/4885SLC6A4 4319/4885SLC6A2 4654/4885 |
| US-20030055076-A1 | Novel compounds, their preparation and use | PPARG, PPARA, PPARD | HTR2A 1500/4885SLC6A4 4487/4885SLC6A2 4593/4885 |
| US-20020111344-A1 | Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma activators | PPARG, PPARA, PPARD | HTR2A 1774/4885SLC6A4 4530/4885SLC6A2 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.