Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1361125 | 0.97 | — | — | |
| SCHEMBL16328342 | 0.97 | — | — | |
| Bromide SCHEMBL238106 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL60952 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL4623968 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL8471902 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL28501646 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL239119 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| Bromide SCHEMBL21253146 | 0.90 | DNM1 (0.44) | CHRNB2CHRNA4CHRNB4DNM1OPRM1 | |
| SCHEMBL1687785 | 0.89 | OPRM1 (0.48) | CHRNB2CHRNA4CHRNB4DNM1CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047674-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036405-A1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVE | EISAI CO., LTD. (JP) | 1999-07-22 | — | — | WO | disclosed |