Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592515 | 0.88 | FGFR1 (0.41) | FGFR1FGFR4SMN1; SMN2NPSR1CCNE1 | |
| SCHEMBL8174616 | 0.88 | FGFR1 (0.41) | FGFR1FGFR4SMN1; SMN2NPSR1CCNE1 | |
| SCHEMBL7396461 | 0.78 | TYK2 (0.42) | FGFR1FGFR4SMN1; SMN2NPSR1CCNE1 | |
| SCHEMBL16593729 | 0.75 | ADORA3 (0.36) | FGFR1FGFR4SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL18076620 | 0.73 | KDM4E (0.51) | FGFR1FGFR4SMN1; SMN2NPSR1CCNE1 | |
| SCHEMBL28263318 | 0.73 | L3MBTL1 (0.47) | FGFR4SMN1; SMN2CCNE1CDK2CDK5 | |
| SCHEMBL27409347 | 0.72 | FGFR1 (0.40) | FGFR1FGFR4SMN1; SMN2CCNE1CDK2 | |
| SCHEMBL8166609 | 0.72 | NPSR1 (0.37) | NPSR1CCNE1CDK2CDK5KMT2A | |
| SCHEMBL12780363 | 0.71 | CXCL8 (0.49) | SMN1; SMN2KMT2AMEN1TP53MDM4 | |
| SCHEMBL19869621 | 0.69 | FFAR1 (0.42) | FGFR1FGFR4SMN1; SMN2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040447-A | REACTING A HALOGENATED AMINO PYRIMIDINE COMPOUND WITH ACID ANHYDRIDE OR ACID HALIDE TO FORM AN INTERMEDIATE, TRANSFORMING THE 6-HALO GROUP OF THE INTERMEDIATE TO AN AMINE BY DISPLACEMENT WITH AMMONIA, CYCLIZING WITH A BASE | EURO-CELTIQUE S.A. | 2000-03-21 | — | — | US | disclosed |
| WO-1999031103-A1 | PREPARATION OF 3-SUBSTITUTED ADENINES | EURO-CELTIQUE S.A. (LU) | 1999-06-24 | — | — | WO | disclosed |