Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 5/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190736 | 0.87 | PARP1 (0.39) | NR3C2PARP1ALDH1A1GAADRD2 | |
| SCHEMBL8202568 | 0.77 | RPS6KA1 (0.39) | ADRB1ADRB2PDE3BPDE3A | |
| SCHEMBL8198682 | 0.73 | NR3C2 (0.34) | NR3C2PARP1ALDH1A1GAADRD2 | |
| SCHEMBL14576785 | 0.72 | NR3C2 (0.36) | NR3C2ALDH1A1GAADRD2DRD4 | |
| SCHEMBL8191321 | 0.71 | MMP12 (0.37) | NR3C2ALDH1A1GAADRD2DRD4 | |
| SCHEMBL13424803 | 0.70 | PARP1 (0.47) | NR3C2PARP1MMP12ADRB1ADRB2 | |
| SCHEMBL13369127 | 0.69 | PARP1 (0.56) | NR3C2PARP1DRD2DRD3MMP12 | |
| SCHEMBL4100343 | 0.67 | DRD2 (0.40) | NR3C2ALDH1A1GAADRD2DRD4 | |
| SCHEMBL12119317 | 0.67 | DRD2 (0.56) | DRD2DRD4DRD3ADRB1ADRB2 | |
| SCHEMBL12116980 | 0.66 | PDE3B (0.53) | NR3C2PARP1DRD2DRD3MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |