Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316242 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL8209732 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL8210418 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL2301745 | 0.77 | KDM4E (0.77) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL16387742 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL30040951 | 0.71 | KDM4E (0.51) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL11470029 | 0.71 | KDM4E (0.69) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL7598160 | 0.71 | KDM4E (0.69) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL30531237 | 0.71 | KDM4E (0.69) | KDM4EALDH1A1GAAL3MBTL1ALOX15 | |
| SCHEMBL23484271 | 0.71 | PKM (0.50) | KDM4EGAATSHRHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | disclosed |