Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16387742 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL2301745 | 0.82 | KDM4E (0.77) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL8201941 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL8210418 | 0.80 | KDM4E (0.52) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL4627602 | 0.78 | TSHR (0.59) | KDM4EALDH1A1GAAL3MBTL1TSHR | |
| SCHEMBL30531237 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL7598160 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL11470029 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1ALOX15GAAL3MBTL1 | |
| SCHEMBL9869186 | 0.75 | CA12 (0.42) | KDM4EALDH1A1ALOX15GAATSHR | |
| SCHEMBL20472390 | 0.75 | KDM4E (0.62) | KDM4EALDH1A1ALOX15GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263648-B2 | Diebenzofuran derivatives as inhibitors of PDE-4 and PDE-10 | Mylan Laboratories Ltd. (IN) | 2012-09-11 | — | — | US | disclosed |
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LABORATORIES LIMITED (IN) | 2009-11-12 | — | — | US | disclosed |
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | PDE4A, PDE4B, PDE12 | KDM4E 393/4885ALDH1A1 234/4885ALOX15 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.