Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202750 | 0.90 | SLC6A9 (0.32) | TACR1ACHE | |
| SCHEMBL8201272 | 0.87 | TACR1 (0.36) | TACR1 | |
| SCHEMBL8201255 | 0.87 | TACR1 (0.32) | TACR1HTR7 | |
| SCHEMBL8202155 | 0.86 | TACR1 (0.43) | TACR1 | |
| SCHEMBL8201838 | 0.86 | SIGMAR1 (0.39) | TACR1ACHETSHRHTR2AHTR2C | |
| SCHEMBL8193781 | 0.74 | SLC6A9 (0.36) | — | |
| SCHEMBL8201159 | 0.73 | TACR1 (0.35) | TACR1 | |
| SCHEMBL8201999 | 0.72 | GRIN2D (0.36) | TACR1ACHESIGMAR1 | |
| SCHEMBL8201993 | 0.72 | TACR1 (0.34) | TACR1HTR2A | |
| SCHEMBL8202470 | 0.71 | TACR1 (0.38) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080740-A | Spiro-ketal derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-27 | — | — | US | claimed |
| US-6080740-A | Spiro-ketal derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-27 | — | — | US | disclosed |