Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201944 | 0.87 | TACR1 (0.38) | TACR1HTR7 | |
| SCHEMBL8202750 | 0.87 | SLC6A9 (0.32) | TACR1 | |
| SCHEMBL8201272 | 0.85 | TACR1 (0.36) | TACR1 | |
| SCHEMBL8202155 | 0.76 | TACR1 (0.43) | TACR1 | |
| SCHEMBL8201838 | 0.75 | SIGMAR1 (0.39) | TACR1 | |
| SCHEMBL8194344 | 0.74 | DRD2 (0.37) | TACR1 | |
| SCHEMBL8201159 | 0.71 | TACR1 (0.35) | TACR1 | |
| SCHEMBL8193781 | 0.70 | SLC6A9 (0.36) | — | |
| SCHEMBL8201993 | 0.70 | TACR1 (0.34) | TACR1 | |
| SCHEMBL8202470 | 0.69 | TACR1 (0.38) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080740-A | Spiro-ketal derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-27 | — | — | US | claimed |
| US-6080740-A | Spiro-ketal derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0880529-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030056-A1 | SPIRO-KETAL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |