Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31727983 | 0.82 | PNP (0.42) | XDHPNPNPSR1MAPTCDK1 | |
| SCHEMBL8212090 | 0.80 | PNP (0.41) | PNPNPSR1CYP1A2MAPTCDK1 | |
| SCHEMBL27443358 | 0.78 | KDM4E (0.34) | XDHTYMPCDK4KDM4ELMNA | |
| SCHEMBL718210 | 0.74 | NPSR1 (0.52) | XDHPNPNPSR1CYP1A2TYMP | |
| SCHEMBL12956972 | 0.74 | CDK1 (0.52) | XDHPNPNPSR1CYP1A2TYMP | |
| SCHEMBL14796354 | 0.72 | NPSR1 (0.40) | PNPNPSR1HIF1AMEN1KMT2A | |
| SCHEMBL22901877 | 0.69 | PNP (0.45) | PNPMAPTHIF1AMITFTP53 | |
| SCHEMBL19506131 | 0.68 | XDH (0.46) | XDHPNPNPSR1CYP1A2TYMP | |
| SCHEMBL12284639 | 0.66 | ALDH1A1 (0.65) | XDHPNPNPSR1CYP1A2MAPT | |
| SCHEMBL22907452 | 0.65 | PNP (0.56) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | disclosed |