Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201987 | 1.00 | HTR6 (0.51) | HTR6HTR1AHTR1BPDE4BHTR2A | |
| SCHEMBL8209786 | 0.89 | HTR6 (0.52) | HTR6HTR1AHTR1BPDE4BHTR2A | |
| SCHEMBL8209783 | 0.89 | HTR6 (0.52) | HTR6HTR1AHTR1BPDE4BHTR2A | |
| SCHEMBL8213323 | 0.87 | HTR6 (0.55) | HTR6HTR1AHTR1BPOLB | |
| SCHEMBL8213328 | 0.87 | HTR6 (0.55) | HTR6HTR1AHTR1BPOLB | |
| SCHEMBL8209078 | 0.86 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8209082 | 0.86 | HTR6 (0.55) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8211649 | 0.83 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8211652 | 0.83 | HTR6 (0.53) | HTR6HTR1AHTR1BHTR2A | |
| SCHEMBL8208584 | 0.83 | HTR6 (0.52) | HTR6HTR1AHTR1BPDE4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |