Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 8/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3521082 | 0.87 | DRD2 (0.43) | DRD2CHRM1DRD4DRD3CHEK1 | |
| SCHEMBL8203995 | 0.87 | BCHE (0.44) | DRD2CHRM1DRD4DRD3CHEK1 | |
| SCHEMBL20067134 | 0.83 | ROS1 (0.42) | DRD2CHRM1DRD1NOX1MEN1 | |
| SCHEMBL20067128 | 0.80 | NOX1 (0.44) | DRD2CHRM1DRD1NOX1MEN1 | |
| SCHEMBL8204505 | 0.80 | TP53 (0.33) | DRD4CHEK1BCHEACHECYP1A2 | |
| SCHEMBL5138230 | 0.80 | TRPA1 (0.47) | CHRM1CHEK1CYP1A2MEN1KMT2A | |
| SCHEMBL309794 | 0.80 | MAPT (0.50) | MEN1KMT2AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL8204796 | 0.76 | CYBB (0.44) | CHRM1NOX1MEN1KMT2AMAPT | |
| SCHEMBL8206931 | 0.76 | TRPA1 (0.51) | CHRM1CYP1A2CYP2D6NOX1MEN1 | |
| SCHEMBL20067130 | 0.73 | CSNK1G1 (0.41) | DRD2DRD1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103715-A | COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-15 | — | — | US | disclosed |
| US-5538965-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1996-07-23 | — | — | US | disclosed |