Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226278 | 0.92 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL29482253 | 0.92 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL8341417 | 0.86 | CRHR1 (0.83) | CRHR1 | |
| SCHEMBL5842798 | 0.84 | CRHR1 (0.81) | CRHR1 | |
| SCHEMBL8342028 | 0.84 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL6798895 | 0.84 | CRHR1 (0.72) | CRHR1 | |
| SCHEMBL6800225 | 0.83 | CRHR1 (0.75) | CRHR1 | |
| SCHEMBL5844424 | 0.83 | CRHR1 (0.83) | CRHR1 | |
| SCHEMBL6799172 | 0.83 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL5845505 | 0.83 | CRHR1 (0.70) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043260-A | Method of treating heart failure | PFIZER INC (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0951906-A1 | Use of 3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridines for treating heart failure | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |