Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202458 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4HRH1 | |
| SCHEMBL8202558 | 0.91 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL7812858 | 0.91 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL7805864 | 0.91 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL9085967 | 0.88 | SLC6A1 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7819333 | 0.87 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL7819304 | 0.87 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL7813062 | 0.87 | ALDH1A1 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4HRH1 | |
| SCHEMBL8194104 | 0.87 | KDM4E (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4CYP3A4 | |
| SCHEMBL9085418 | 0.87 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738262-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2000-04-19 | — | — | EP | claimed |