Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 9/20 | 0.45 |
| ▸ | PGR | P06401 | 5/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705085 | 0.83 | NR3C2 (0.50) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL3600619 | 0.81 | IL4I1 (0.44) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL4102483 | 0.80 | NR3C2 (0.45) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL29939223 | 0.80 | NR3C2 (0.45) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL30330297 | 0.80 | PDE3B (0.41) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL25166226 | 0.80 | PDE3B (0.41) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL12116980 | 0.80 | PDE3B (0.53) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL21552373 | 0.80 | PGR (0.45) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL21372202 | 0.80 | NR3C2 (0.48) | NR3C2PGRNR3C1MMP12PDE3B | |
| SCHEMBL19629960 | 0.80 | NR3C2 (0.45) | NR3C2PGRNR3C1MMP12PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063668-A1 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |