Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426774 | 1.00 | MAPT (0.34) | MAPTALDH1A1PTGS1DPP4FAP | |
| SCHEMBL12867478 | 1.00 | MAPT (0.34) | MAPTALDH1A1PTGS1DPP4FAP | |
| Hydrochloric Acid SCHEMBL1174259 | 0.98 | DPP4 (0.33) | MAPTALDH1A1PTGS1DPP4FAP | |
| SCHEMBL25600609 | 0.83 | MAPT (0.31) | MAPTALDH1A1PTGS1DPP4 | |
| SCHEMBL17617087 | 0.83 | MAPT (0.31) | MAPTALDH1A1PTGS1DPP4 | |
| SCHEMBL19009024 | 0.83 | MAPT (0.31) | MAPTALDH1A1PTGS1DPP4 | |
| SCHEMBL1174655 | 0.80 | DPP4 (0.50) | MAPTALDH1A1PTGS1DPP4FAP | |
| SCHEMBL342534 | 0.80 | DPP4 (0.50) | MAPTALDH1A1PTGS1DPP4FAP | |
| SCHEMBL343358 | 0.80 | DPP4 (0.50) | MAPTALDH1A1PTGS1DPP4FAP | |
| Trifluoroacetic Acid SCHEMBL7399856 | 0.79 | DPP4 (0.42) | MAPTALDH1A1PTGS1DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017889-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-01-25 | — | — | US | disclosed |
| EP-0740655-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5902791-A | TREATING RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTAL DISEASE, GINGIVITIS, CORNEAL ULCERATION OR TUMOR METASTASES | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-05-11 | — | — | US | disclosed |
| EP-0740655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-11-06 | — | — | EP | disclosed |
| WO-1995019961-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-07-27 | — | — | WO | disclosed |