Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 14/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195706 | 0.87 | NISCH (0.52) | NISCHMAOAMAOBTOP2ATOP2B | |
| SCHEMBL8200553 | 0.83 | NISCH (0.60) | NISCHMAOAMAOBTOP2ATOP2B | |
| SCHEMBL8195231 | 0.83 | NISCH (0.55) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8195501 | 0.81 | NISCH (0.53) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8197166 | 0.81 | NISCH (0.60) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8196239 | 0.77 | LMNA (0.47) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8222744 | 0.77 | NISCH (0.44) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8187862 | 0.77 | NISCH (0.56) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8187010 | 0.76 | LMNA (0.58) | NISCHALDH1A1CYP1A2HPGDCASP1 | |
| SCHEMBL8219724 | 0.76 | TOP2A (0.43) | NISCHALDH1A1CYP1A2HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000078726-A1 | IMIDAZOLINE DERIVATIVES FOR THE TREATMENT OF DIABETES, ESPECIALLY TYPE II DIABETES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |