SCHEMBL8203012

SCHEMBL8203012

O=CN1CC2CC(C1)c1cc3nccnc3cc12

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 6/20 0.51
CHRNA4 P43681 6/20 0.51
CHRNB4 P30926 2/20 0.51
CHRNA3 P32297 2/20 0.51
CHRNA1 P02708 1/20 0.51
ESR1 P03372 1/20 0.51
CHRNG P07510 1/20 0.51
CHRNB1 P11230 1/20 0.51
CHRNA5 P30532 1/20 0.51
CHRNA7 P36544 1/20 0.51
HTR3A P46098 1/20 0.51
CHRND Q07001 1/20 0.51
CHRNA2 Q15822 1/20 0.51
CYP2C9 P11712 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
HSD17B10 Q99714 1/20 0.34
FLT3 P36888 1/20 0.31
GSK3B P49841 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29707872 1.00 CHRNB2 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL2741393 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL14003843 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL14101255 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL13561410 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL24827106 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL8027306 0.77 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL25064560 0.76 CHRNB2 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL29761233 0.76 CHRNB2 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1
SCHEMBL24168628 0.76 CHRNB2 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11872234-B2 Vareniciline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2024-01-16 US disclosed
US-11872234-B2 Vareniciline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2024-01-16 US disclosed
US-11872234-B2 Vareniciline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2024-01-16 US disclosed
US-11779587-B2 Vareniciline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2023-10-10 US disclosed
US-11779587-B2 Vareniciline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2023-10-10 US disclosed
US-20230285406-A1 VARENICILINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF WILMINGTON SAVINGS FUND SOCIETY, FSB, AS COLLATERAL AGENT 2023-09-14 US disclosed
US-20230285406-A1 VARENICILINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF WILMINGTON SAVINGS FUND SOCIETY, FSB, AS COLLATERAL AGENT 2023-09-14 US disclosed
US-20230285404-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF ENDO OPERATIONS LIMITED (IE) 2023-09-14 US disclosed
US-20230285404-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF ENDO OPERATIONS LIMITED (IE) 2023-09-14 US disclosed
US-20230285404-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF ENDO OPERATIONS LIMITED (IE) 2023-09-14 US disclosed
US-11717524-B1 Varenicline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2023-08-08 US disclosed
US-11717524-B1 Varenicline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2023-08-08 US disclosed
US-11602537-B2 Varenicline compound and process of manufacture thereof PAR PHARMACEUTICAL, INC. (US) 2023-03-14 US disclosed
US-20220249508-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF WILMINGTON SAVINGS FUND SOCIETY, FSB, AS COLLATERAL AGENT 2022-08-11 US disclosed
WO-2022147189-A1 VARENICLINE PRODRUGS ANTARES PHARMA, INC. (US) 2022-07-07 WO disclosed
US-20100062046-A1 POLYMORPHS OF NICOTINIC INTERMEDIATES ALLEN DOUGLAS J M 2010-03-11 US disclosed
US-20100062046-A1 POLYMORPHS OF NICOTINIC INTERMEDIATES ALLEN DOUGLAS J M 2010-03-11 US disclosed
EP-1451202-B1 ARYL FUSED AZAPOLYCYCLIC COMPOUNDS PFIZER PROD INC (US) 2008-08-20 EP disclosed
WO-2008060487-A2 POLYMORPHS OF NICOTINIC INTERMEDIATES PFIZER PRODUCTS INC. (US) 2008-05-22 WO disclosed
WO-2004103372-A1 PHARMACEUTICAL COMPOSITIONS OF VARENICLINE PFIZER PRODUCTS INC. (US) 2004-12-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220249508-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF COMT, CYP2C9, CYP3A7 CHRNB2 49/4885CHRNA4 41/4885CHRNB4 43/4885
US-11717524-B1 Varenicline compound and process of manufacture thereof COMT, CYP2C9, CYP3A7 CHRNB2 49/4885CHRNA4 41/4885CHRNB4 43/4885
US-11779587-B2 Vareniciline compound and process of manufacture thereof COMT, CYP2C9, CYP3A7 CHRNB2 88/4885CHRNA4 82/4885CHRNB4 101/4885
US-11602537-B2 Varenicline compound and process of manufacture thereof COMT, CYP2C9, CYP3A7 CHRNB2 49/4885CHRNA4 41/4885CHRNB4 43/4885
US-20100062046-A1 POLYMORPHS OF NICOTINIC INTERMEDIATES NAPRT, NAMPT, NNMT CHRNB2 22/4885CHRNA4 4/4885CHRNB4 8/4885
US-20230285404-A1 VARENICLINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF COMT, CYP2C9, CYP3A7 CHRNB2 49/4885CHRNA4 41/4885CHRNB4 43/4885
US-11872234-B2 Vareniciline compound and process of manufacture thereof COMT, CYP2C9, CYP3A7 CHRNB2 88/4885CHRNA4 82/4885CHRNB4 101/4885
US-20230285406-A1 VARENICILINE COMPOUND AND PROCESS OF MANUFACTURE THEREOF COMT, CYP2C9, CYP3A7 CHRNB2 88/4885CHRNA4 82/4885CHRNB4 101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.