SCHEMBL8203016

SCHEMBL8203016

C=C(OCC)c1nc2sc(CC)cc2c(=O)[nH]1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.55
TMIGD3 P0DMS9 5/20 0.55
ADORA1 P30542 4/20 0.55
SMN1; SMN2 Q16637 3/20 0.51
KDM4E B2RXH2 5/20 0.50
RAB9A P51151 3/20 0.50
HPGD P15428 3/20 0.50
NPC1 O15118 2/20 0.48
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
AGTR1 P30556 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
CYP1A2 P05177 3/20 0.46
CYP2C9 P11712 3/20 0.46
BRD4 O60885 1/20 0.42
POLB P06746 2/20 0.41
GAA P10253 2/20 0.41
CYP2C19 P33261 1/20 0.41
F2 P00734 1/20 0.39
HSD17B10 Q99714 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8200644 0.86 ALDH1A1 (0.57) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL8198112 0.85 SMN1; SMN2 (0.47) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL8189842 0.84 TMIGD3 (0.60) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL8195845 0.83 ALDH1A1 (0.40) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL8195380 0.81 ALDH1A1 (0.39) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL13343603 0.80 TMIGD3 (0.61) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL8198855 0.80 RAB9A (0.61) ALDH1A1SMN1; SMN2KDM4ERAB9AHPGD
SCHEMBL1970640 0.80 ALDH1A1 (0.61) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL11499002 0.77 ALDH1A1 (0.52) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E
SCHEMBL1967325 0.77 KDM4E (0.55) ALDH1A1TMIGD3ADORA1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008063668-A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS ALANTOS PHARMACEUTICALS HOLDING, INC. (US) 2008-05-29 WO disclosed