Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203327 | 0.88 | SGMS2 (0.82) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL8204602 | 0.88 | RAB9A (0.60) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL875474 | 0.87 | SGMS2 (1.00) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL7348393 | 0.83 | SGMS2 (0.65) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL8202380 | 0.83 | RAB9A (0.62) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL28376684 | 0.83 | MAPT (0.63) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL6959181 | 0.83 | MAPT (0.67) | SGMS2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7339795 | 0.82 | SGMS2 (0.57) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL3814319 | 0.82 | SGMS2 (0.80) | SGMS2GAAMEN1KMT2ANPC1 | |
| SCHEMBL978857 | 0.81 | HTT (0.64) | SGMS2GAAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136969-A | PROTEIN KINASE INHIBITORS; 4-HYDROXYBENZOIC ACID 3-(4-(4-FLUOROBENZOYLOXY)-BENZOYLAMINO)-AZEPAN-4-YL ESTER | HOFFMANN-LA ROCHE INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-5907038-A | PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1999-05-25 | — | — | US | disclosed |
| EP-0836592-A1 | AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002249-A1 | NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-23 | — | — | WO | disclosed |