Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28158669 | 0.86 | SMN1; SMN2 (0.43) | HPGDSMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL8204872 | 0.80 | CES2 (0.56) | NPC1HPGDSMN1; SMN2LMNARAB9A | |
| SCHEMBL8215240 | 0.78 | CES2 (0.54) | MEN1KMT2APOLBCES2CES1 | |
| SCHEMBL6984913 | 0.77 | TDP1 (0.47) | NPC1HPGDSMN1; SMN2LMNAALPG | |
| SCHEMBL28043394 | 0.75 | NPC1 (0.53) | NPC1HPGDSMN1; SMN2LMNAALPG | |
| SCHEMBL9729472 | 0.75 | NPC1 (0.47) | NPC1HPGDSMN1; SMN2LMNAALPG | |
| SCHEMBL10518218 | 0.74 | NPC1 (0.48) | NPC1HPGDSMN1; SMN2LMNAALPG | |
| SCHEMBL6312637 | 0.74 | NPC1 (0.48) | NPC1HPGDSMN1; SMN2LMNAALPG | |
| SCHEMBL8213488 | 0.74 | CES2 (0.48) | NPC1HPGDSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL12043751 | 0.72 | MLYCD (0.70) | NPC1SMN1; SMN2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057290-A | ADMINISTERING A CYSTEINE PROTEASE INHIBITOR TO A PATIENT FOR INHIBITING ANGIOGENESIS | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2000-05-02 | — | — | US | disclosed |