Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279 | 0.87 | TDP1 (0.58) | TDP1L3MBTL1LMNAALDH1A1POLB | |
| SCHEMBL8638260 | 0.84 | CYP1A2 (0.46) | TDP1NPC1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL9803692 | 0.78 | TDP1 (0.73) | TDP1L3MBTL1NPC1LMNAHPGD | |
| SCHEMBL8203529 | 0.77 | NPC1 (0.47) | TDP1NPC1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL16807287 | 0.76 | L3MBTL1 (0.77) | TDP1L3MBTL1NPC1LMNAHPGD | |
| SCHEMBL28248573 | 0.75 | MEN1 (0.54) | TDP1L3MBTL1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL16799032 | 0.75 | CES2 (0.47) | TDP1L3MBTL1NPC1LMNAHPGD | |
| SCHEMBL3985471 | 0.72 | HDAC3 (0.53) | TDP1L3MBTL1NPC1LMNAHPGD | |
| SCHEMBL27545340 | 0.72 | HDAC3 (0.53) | TDP1L3MBTL1NPC1LMNAHPGD | |
| SCHEMBL10518218 | 0.72 | NPC1 (0.48) | TDP1NPC1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | claimed |