Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.67 |
| ▸ | ACACB | O00763 | 5/20 | 0.51 |
| ▸ | ACACA | Q13085 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178583 | 0.86 | ALOX5 (0.52) | ALOX5ACACBACACASMN1; SMN2HAO1 | |
| SCHEMBL8198208 | 0.84 | ALOX5 (0.61) | ALOX5ACACBACACAMAPTMEN1 | |
| Fenleuton SCHEMBL74861 | 0.81 | ALOX5 (1.00) | ALOX5ACACBACACAMAPTMEN1 | |
| Fenleuton SCHEMBL31539081 | 0.81 | ALOX5 (1.00) | ALOX5ACACBACACAMAPTMEN1 | |
| SCHEMBL8198163 | 0.80 | ALOX5 (0.65) | ALOX5ACACBMAPTMEN1ALDH1A1 | |
| SCHEMBL13140097 | 0.78 | ALOX5 (0.83) | ALOX5ACACBACACAMAPTMEN1 | |
| SCHEMBL8189700 | 0.77 | ALOX5 (0.61) | ALOX5MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL9422278 | 0.76 | ALOX5 (0.56) | ALOX5ACACBACACAALDH1A1LMNA | |
| SCHEMBL5942804 | 0.75 | ACACB (0.78) | ACACBACACA | |
| SCHEMBL9121577 | 0.73 | ALOX5 (0.52) | ALOX5ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850217-B1 | PROCESS FOR THE PREPARATION OF ARYLALKYNYL-N-HYDROXYUREA DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 2000-04-05 | — | — | EP | disclosed |