SCHEMBL8203592

SCHEMBL8203592

CC(C)(C)OC(=O)c1ccc(-n2[nH]cc(-c3cncc(Br)c3)c2=O)nc1

nearest known ligand 0.73

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
P4HTM Q9NXG6 3/20 0.73
EGLN1 Q9GZT9 18/20 0.55
TET2 Q6N021 1/20 0.55
OGFOD1 Q8N543 1/20 0.55
TET1 Q8NFU7 1/20 0.55
EGLN2 Q96KS0 1/20 0.55
HIF1AN Q9NWT6 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27764493 0.99 P4HTM (0.72) P4HTMEGLN1TET2OGFOD1TET1
SCHEMBL8182341 0.85 P4HTM (0.72) P4HTMEGLN1TET2OGFOD1TET1
Hydrochloric Acid SCHEMBL17938030 0.85 P4HTM (0.62) P4HTMEGLN1TET2OGFOD1TET1
SCHEMBL8197743 0.85 P4HTM (1.00) P4HTMEGLN1
Hydrochloric Acid SCHEMBL27786207 0.84 P4HTM (0.71) P4HTMEGLN1TET2OGFOD1TET1
Hydrochloric Acid SCHEMBL3618381 0.84 P4HTM (0.98) P4HTMEGLN1
SCHEMBL3836971 0.79 P4HTM (0.74) P4HTMEGLN1
Hydrochloric Acid SCHEMBL17938029 0.78 P4HTM (0.72) P4HTMEGLN1
SCHEMBL3706371 0.74 EGLN2 (0.69) P4HTMEGLN1TET2OGFOD1TET1
SCHEMBL3594699 0.74 VHL (0.60) P4HTMEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097404-B1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER IP GMBH (DE) 2016-07-27 EP disclosed
US-20100093803-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERRING PHARMA AKTIENGELLSCHAFT (DE) 2010-04-15 US disclosed
WO-2008067874-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-06-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100093803-A1 SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF DCK, THPO, QDPR P4HTM 412/4885EGLN1 882/4885TET2 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.