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SCHEMBL8203822

SCHEMBL8203822

O=C(NS(=O)(=O)c1ccc(Cl)cc1)c1ccc(C(=O)C(=O)c2ccc(C(=O)NS(=O)(=O)c3ccc(Br)cc3)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FLT1 P17948 13/20 0.77
▸ FLT4 P35916 13/20 0.77
▸ KDR P35968 13/20 0.77
▸ L3MBTL1 Q9Y468 1/20 0.66
▸ EGFR P00533 5/20 0.63
▸ PTGS1 P23219 2/20 0.62
▸ PTGS2 P35354 2/20 0.62
▸ ERBB2 P04626 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10989349 0.87 FLT1 (1.00) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL7287948 0.81 FLT1 (0.87) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL9014174 0.81 FLT1 (0.87) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL24224258 0.80 FLT1 (0.84) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL789891 0.80 FLT1 (0.84) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL9176789 0.80 FLT1 (0.84) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL24347999 0.80 PTGS2 (0.67) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL4464235 0.80 PTGS2 (0.71) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL9176247 0.80 FLT1 (1.00) FLT1FLT4KDRL3MBTL1EGFR
SCHEMBL31060379 0.78 FLT1 (1.00) FLT1FLT4KDRL3MBTL1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863915-B1 ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES HOECHST MARION ROUSSEL INC (US) 2000-02-02 — — EP claimed