SCHEMBL8204517

SCHEMBL8204517

CC(=O)NC(=O)Cc1ccc(Cl)cc1Cl

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ERCC1 P07992 5/20 0.54
ERCC4 Q92889 5/20 0.54
P2RX7 Q99572 3/20 0.54
GALR3 O60755 1/20 0.52
NR2F2 P24468 1/20 0.52
ALDH1A1 P00352 3/20 0.50
KMT2A Q03164 3/20 0.50
HTT P42858 2/20 0.50
RECQL P46063 1/20 0.50
GAA P10253 1/20 0.50
KDM4E B2RXH2 1/20 0.50
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
MEN1 O00255 2/20 0.47
THRB P10828 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4247795 0.83 ERCC1 (0.56) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL29712851 0.80 IDO1 (0.50) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL157921 0.80 IDO1 (0.50) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL8424664 0.80 ERCC1 (0.61) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL30545006 0.79 ALDH1A1 (0.65) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL6529545 0.79 LMNA (0.60) ERCC1ERCC4P2RX7ALDH1A1KMT2A
SCHEMBL9523440 0.79 ALDH1A1 (0.65) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL8233977 0.79 KDM4E (0.62) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL12366792 0.79 RECQL (0.55) ERCC1ERCC4P2RX7GALR3NR2F2
SCHEMBL435206 0.76 IDO1 (0.54) ERCC1ERCC4P2RX7ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6093851-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2000-07-25 US disclosed
EP-0735018-B1 N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL CO (JP) 1999-07-21 EP disclosed
US-5739401-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-04-14 US disclosed
EP-0735018-A1 N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 EP disclosed