SCHEMBL8204765

SCHEMBL8204765

C=Cc1ccc2c(c1)Oc1cc(C=C)ccc1N2

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 5/20 0.41
ALDH1A1 P00352 2/20 0.40
TP53 P04637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HTR2B P41595 1/20 0.33
TRPA1 O75762 1/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8205103 0.81 ALOX5 (0.40) ALOX5HTR2B
SCHEMBL7521065 0.80 ALOX5 (0.60) ALOX5ALDH1A1TDP1HTR2B
SCHEMBL30811558 0.79 ALDH1A1 (0.47) ALOX5ALDH1A1TDP1HTR2BTSHR
SCHEMBL27344294 0.79 ALDH1A1 (0.47) ALOX5ALDH1A1TDP1HTR2BTSHR
SCHEMBL2117538 0.78
SCHEMBL23242512 0.76 MAPT (0.46) ALDH1A1TP53TDP1
SCHEMBL29800621 0.76 MAPT (0.46) ALDH1A1TP53TDP1
SCHEMBL23242583 0.76 MAPT (0.46) ALDH1A1TP53TDP1
Hydrogen Sulfide SCHEMBL26596717 0.76 ALDH1A1 (0.46) ALDH1A1TP53TDP1TRPA1TSHR
SCHEMBL27443097 0.74 CYP11B1 (0.49) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6083651-A SOLUBLE IN POLYMERIC BINDERS TAKASAGO INTERNATIONAL CORPORATION (JP) 2000-07-04 US disclosed
US-5942615-A GOOD SOLUBILITY IN BINDER POLYMERS, SENSITIVITY, AND LOW RESIDUAL POTENTIAL TAKASAGO INTERNATIONAL CORPORATION (JP) 1999-08-24 US disclosed