Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.55 |
| ▸ | MST1R | Q04912 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204790 | 1.00 | POLB (0.58) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL15421407 | 0.79 | CA2 (0.73) | POLBALDH1A1CA2GSK3BMEN1 | |
| SCHEMBL15421403 | 0.79 | CA2 (0.73) | POLBALDH1A1CA2GSK3BMEN1 | |
| SCHEMBL15312912 | 0.79 | KDM4E (0.55) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL622599 | 0.79 | KDM4E (0.55) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL7557643 | 0.78 | GSK3B (0.51) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL4324078 | 0.77 | ALDH1A1 (0.55) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL1429142 | 0.77 | ALDH1A1 (0.55) | POLBNTRK1NTRK3NTRK2PRKD3 | |
| SCHEMBL8197809 | 0.76 | PIM1 (0.48) | POLBALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL8197811 | 0.76 | PIM1 (0.48) | POLBALDH1A1GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |