Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190907 | 0.96 | LMNA (0.34) | MEN1KMT2APOLBCASP6LMNA | |
| Hydrochloric Acid SCHEMBL8205122 | 0.94 | LMNA (0.33) | MEN1KMT2APOLBCASP6LMNA | |
| Hydrochloric Acid SCHEMBL8206694 | 0.94 | LMNA (0.33) | MEN1KMT2APOLBCASP6LMNA | |
| SCHEMBL5079126 | 0.85 | AKR1B1 (0.38) | MEN1KMT2APOLBCASP6LMNA | |
| SCHEMBL8205903 | 0.77 | HSD17B10 (0.36) | POLBMAPK1KDM4EALDH1A1MAPT | |
| SCHEMBL4563591 | 0.75 | LMNA (0.40) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL6188489 | 0.75 | SMN1; SMN2 (0.41) | POLBLMNATSHRKDM4EALDH1A1 | |
| SCHEMBL9933267 | 0.75 | KDM4E (0.33) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL28760203 | 0.72 | TDP1 (0.32) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7377317 | 0.72 | TRPA1 (0.37) | MEN1KMT2APOLBCASP6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979227-A1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998047882-A1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-10-29 | — | — | WO | disclosed |