Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926095 | 0.87 | PIK3CD (0.53) | MEN1KMT2AMAPTPIK3CAMTOR | |
| SCHEMBL8218782 | 0.86 | PIK3CA (0.54) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8213175 | 0.86 | PIK3CA (0.51) | RAB9ANPC1MEN1KMT2APIK3CA | |
| SCHEMBL8216854 | 0.84 | PIK3CA (0.52) | MEN1KMT2APIK3CAMTORPIK3CD | |
| SCHEMBL11925398 | 0.84 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2RAB9ANPC1L3MBTL1 | |
| SCHEMBL8205071 | 0.84 | PIK3CA (0.54) | ALDH1A1MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL8215041 | 0.83 | PIK3CA (0.66) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8216901 | 0.83 | PIK3CA (0.53) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL3594850 | 0.83 | PIK3CA (0.77) | CYP2C9PIK3CAMTORPIK3CD | |
| SCHEMBL8213915 | 0.82 | PIK3CA (0.49) | SMN1; SMN2RAB9ANPC1PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |