Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205222 | 0.86 | ALDH1A1 (0.53) | PIK3CAMTORRAB9ANPC1PIK3CD | |
| SCHEMBL11926810 | 0.86 | PIK3CA (0.49) | PIK3CAMTORRAB9APOLBNPC1 | |
| SCHEMBL8205071 | 0.84 | PIK3CA (0.54) | PIK3CAMTORPOLBPIK3CDKMT2A | |
| SCHEMBL8218782 | 0.84 | PIK3CA (0.54) | PIK3CAMTORRAB9APOLBNPC1 | |
| SCHEMBL8215041 | 0.83 | PIK3CA (0.66) | PIK3CAMTORRAB9ANPC1PIK3CD | |
| SCHEMBL8216901 | 0.83 | PIK3CA (0.53) | PIK3CAMTORRAB9ANPC1PIK3CD | |
| SCHEMBL3598143 | 0.83 | MTOR (0.77) | PIK3CAMTORPOLBPIK3CD | |
| SCHEMBL8215047 | 0.82 | PIK3CA (0.55) | PIK3CAMTORPIK3CDKMT2AMEN1 | |
| SCHEMBL8222525 | 0.82 | RAB9A (0.48) | PIK3CAMTORRAB9APOLBNPC1 | |
| SCHEMBL8216854 | 0.82 | PIK3CA (0.52) | PIK3CAMTORPIK3CDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |