Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219414 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTALDH1A1P2RX7KDM4E | |
| SCHEMBL14158476 | 0.76 | P2RX7 (0.39) | P2RX7 | |
| SCHEMBL22267604 | 0.72 | GSK3B (0.55) | SMN1; SMN2MAPTEGFRGSK3BRXFP1 | |
| SCHEMBL1377394 | 0.71 | GSK3B (0.58) | CDK1CDK2GSK3B | |
| SCHEMBL4300704 | 0.71 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14564361 | 0.70 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTALDH1A1KDM4EGSK3B | |
| SCHEMBL9328808 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL9323964 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALDH1A1EGFRGSK3B | |
| SCHEMBL6016609 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALDH1A1GSK3B | |
| SCHEMBL23914767 | 0.69 | MAP2K4 (0.51) | SMN1; SMN2MAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040995-A9 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LTD (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040995-A1 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |