Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22267604 | 0.89 | GSK3B (0.55) | SMN1; SMN2GSK3BMAP2K4NR4A2MAPT | |
| SCHEMBL119757 | 0.86 | ALDH1A1 (0.55) | SMN1; SMN2GSK3BMAPTALDH1A1SIRT1 | |
| SCHEMBL13013280 | 0.83 | GSK3B (0.46) | GSK3BMAP2K4NR4A2FADS1JAK2 | |
| SCHEMBL6016427 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2GSK3BMAPTALDH1A1JAK2 | |
| SCHEMBL3363383 | 0.82 | LMNA (0.49) | GSK3BMAP2K4MAPTALDH1A1FADS1 | |
| SCHEMBL11133828 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2GSK3BALDH1A1SIRT1 | |
| SCHEMBL10927575 | 0.81 | LMNA (0.48) | GSK3BMAP2K4MAPTALDH1A1FADS1 | |
| SCHEMBL10931244 | 0.81 | LMNA (0.48) | GSK3BMAP2K4MAPTALDH1A1FADS1 | |
| SCHEMBL13062144 | 0.81 | SIRT1 (0.52) | GSK3BMAP2K4FADS1JAK2JAK1 | |
| SCHEMBL8323107 | 0.80 | FADS1 (0.40) | GSK3BMAP2K4FADS1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5330997-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236945-A | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0325375-B1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1989006651-A1 | 1H-INDAZOLE-3-ACETIC ACIDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0325375-A1 | 1H-indazole-3-acetic acids as aldose reductase inhibitors | PFIZER INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| EP-0040418-B1 | PROCESS FOR PREPARING AN 1H-INDAZOL-3-YLACETIC ACID DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-07-03 | — | — | EP | disclosed |
| EP-0040418-A1 | Process for preparing an 1H-indazol-3-ylacetic acid derivative | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-11-25 | — | — | EP | disclosed |
| EP-0008759-A2 | New process for preparing an 1H-indazol-3-ylacetic acid derivative | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-03-19 | — | — | EP | disclosed |
| US-4008070-A | ALKYL 5-HALO-1H-INDAZOLE-3-ACETATE | NISSAN CHEMICAL INDUSTRIES CO., LTD. (JA) | 1977-02-15 | — | — | US | disclosed |