Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.62 |
| ▸ | MYC | P01106 | 3/20 | 0.61 |
| ▸ | MAX | P61244 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205853 | 1.00 | HSD17B3 (0.62) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL1124983 | 0.79 | MYC (0.74) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL1124985 | 0.79 | MYC (0.74) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL18103053 | 0.78 | MAPK1 (0.72) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL20005672 | 0.78 | MAPK1 (0.72) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL20816065 | 0.76 | MYC (1.00) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL20816067 | 0.76 | MYC (1.00) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL8308291 | 0.74 | PDE4B (0.78) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL8308289 | 0.74 | PDE4B (0.78) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 | |
| SCHEMBL18103074 | 0.73 | SYK (0.74) | HSD17B3MYCMAXALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | claimed |
| WO-2000032598-A9 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC (US) | 2000-11-30 | — | — | WO | disclosed |
| WO-2000032598-A1 | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES UTILIZING INHIBITORS OF TUMOR NECROSIS FACTOR ACTIVITY | STRUCTURAL BIOINFORMATICS INC. (US) | 2000-06-08 | — | — | WO | disclosed |