Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437809 | 0.84 | POLB (0.58) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL10601188 | 0.81 | LOXL2 (0.50) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL6632472 | 0.80 | POLB (0.79) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL177812 | 0.80 | POLB (1.00) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL9969478 | 0.79 | LOXL2 (0.48) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL9969481 | 0.79 | LOXL2 (0.48) | POLBMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL19938078 | 0.79 | LOXL2 (0.58) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19938068 | 0.79 | TSHR (0.55) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18118460 | 0.79 | TSHR (0.55) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9969480 | 0.79 | TSHR (0.55) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037880-A1 | RETINOIC ACID MIMETIC ANILIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029674-A1 | RETINOIC ACID MIMETIC ANILIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-06-17 | — | — | WO | disclosed |