Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28564954 | 0.85 | NPC1 (0.64) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL8207158 | 0.84 | NPC1 (0.54) | CASP3NPC1RAB9APOLBMGLL | |
| SCHEMBL8206774 | 0.83 | CASP3 (0.47) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL8197914 | 0.78 | TACR3 (0.55) | CASP3NPC1RAB9ATP53MAPT | |
| SCHEMBL16088310 | 0.77 | NPC1 (0.61) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL3041603 | 0.75 | NPC1 (0.58) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL4201818 | 0.74 | NPC1 (0.57) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL6929631 | 0.74 | NPC1 (0.63) | CASP3NPC1RAB9AMAOASMN1; SMN2 | |
| SCHEMBL15720647 | 0.73 | CA12 (0.63) | NPC1RAB9ASMN1; SMN2POLBMGLL | |
| SCHEMBL17997751 | 0.73 | NPC1 (0.58) | CASP3NPC1RAB9AMAOASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979227-A1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998047882-A1 | 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-10-29 | — | — | WO | disclosed |