Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 8/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034429 | 0.76 | ESR1 (0.41) | CYP3A4ESR1 | |
| SCHEMBL1501838 | 0.76 | IDO1 (0.53) | HSD17B2HSD17B1CYP17A1FYNMKNK1 | |
| Propane SCHEMBL5843489 | 0.72 | HSD17B1 (0.71) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 | |
| Alcohol SCHEMBL9461730 | 0.71 | HSD17B1 (0.68) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 | |
| SCHEMBL22006701 | 0.70 | ADRA1A (0.35) | — | |
| Alcohol SCHEMBL23879308 | 0.69 | HSD17B1 (0.65) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 | |
| SCHEMBL27593555 | 0.68 | PCSK9 (0.40) | CYP2C9CYP1A2CYP2C19 | |
| Pentane SCHEMBL28008463 | 0.67 | HSD17B1 (0.62) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 | |
| Propane SCHEMBL27565820 | 0.67 | HSD17B1 (0.70) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 | |
| Alcohol SCHEMBL23879306 | 0.67 | HSD17B1 (0.62) | HSD17B2HSD17B1CYP3A4CYP2C9CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986560-A1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-22 | — | — | EP | claimed |
| WO-1998055482-A1 | PYRROLO[2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | claimed |
| EP-0986560-A1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055482-A1 | PYRROLO[2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |